My mom has a cold (she tested negative for Covid). My sister suggested she take a yellow medicinal syrup called "three sixes", ie. "666"; she said it tastes horrible but works good.
I never heard of this brand. My initial search results only returned these Smithsonian Institute pages on a medicine from the 1940s:
666 Cold Preparation - contained antipyrine; ammonium chloride; magnesium sulphate (Epsom salt); citric acid.
666 Liquid - contained quinine and could be used against malaria as well as colds. Active ingredients: quinine sulphate; solution of iron perchloride; citrated caffeine; epsom salt; citric acid.
Those didn't look like products that would be sold in the modern day.
Mistral suggested my sister might have meant
Triaminic as it comes in a yellow version which
people on Reddit say
tasted horrible (whereas the orange one tasted good).
That was plausible, as "Tri" = Three. Maybe the sixes got dropped from the name. There was a
variety pack which had "6" listed on each side of the box. Triaminic is very familiar brand name to me though I don't recall ever taking it. I was surprised to find that it is no longer sold in the U.S.
Triaminic Cold and Cough medicine contained chlorpheniramine, dextromethorphan, and pseudoephedrine.
Another
Triaminic medicine contained chlorpheniramine and phenylpropanolamine. This page says
"The Triaminic brand name and all generics (if any) have been discontinued in the United States."Perhaps because
"Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain)".There were also
recalls due to faulty child safety caps (something that likely wasn't an issue with the yellow syrup, but probably was with the orange one, based on those reddit comments).
The reddit threads about Triaminic had 2 curious comments:
Jbowen0020 3 years ago: Remember 666 cold med, the old formula that tasted awful but worked? The one that had quinine in it? Ya know, like hydroxychloroquine ?
...
No-Standard9405 3 years ago: I remember that flavor and a different cough syrup that was worse then that. It was in the same color family. I think it had epsom salts in it.I went back to searching for info on that.
Who remembers 666 cold medicine? (from 2024 on reddit, with a good photo of a "666 Preparation with Quinine" product)
This
eBay listing, "Vintage 666 Cold Preparation Bottles ~ Jacksonville, FL **Empty Bottles**" seems to show an expiration date of 1984 on the bottles.
Whoa, here's a whole article from 2018 about the company that made the product:
666 Building was iconic landmark.
The original formula hasn’t been available in decades, Foster said. No one can make the old formula that was 40 percent alcohol and contained codeine, quinine, a cough suppressant and a very strong laxative, he said.
... Its modern formulation, without the alcohol and other potent ingredients, survived for a while as mainly a generic daytime cough suppressant...A page at
weirduniverse.net states
"666 cold medicine is no longer available, but it was widely sold and advertised throughout the 20th century. I believe it was only discontinued in the early 21st century."The product was called "Six Sixty Six" as well as "Three Sixes". The page links to an interesting
1954 article about the company in "Sponsor" magazine, which I haven't had time to read.
I found the company's current website:
New Genesis Monticello Drug.
Per the internet archive, 666 Cold Preparation was still sold as late as
September and December 2016.
By 2017, it was no longer for sale on the web site.
Side note: The company currently makes an interesting product called
Nullo.
Nullo® is an internal deodorant for body odor that doesn't mask the problem, instead Nullo neutralizes the odor causing elements in your system. Nullo is a water soluble isolate of chlorophyll (chlorophyllin copper) that regulates the metabolic output of your body's natural bacterial flora to capture and suppress the odor producing elements.
Nullo is a dietary supplement recommended for use to control strong personal odors such as halitosis (bad breath), underarm odor (arm pit), body odor, foot odor, vaginal odor, menstrual odor and odor arising from incontinence. Nullo provides relief and improved quality of life for persons with profound sweat and body odor as may accompany hyperhidrosis [excessive sweating], strong flatus odor, and those with foot odor, smelly feet or stinky shoes. Nullo is also used to reduce odor from incontinence by reducing fecal odors and provides benefit in the case of colostomy, ileostomy, lap band, and bariatric procedures.
(A different website mentioned deer hunters using Nullo to prevent the deer from smelling them.)
Back to the sixes.
Here's another
reddit thread about the 666 brand cold medicine.
It links to a
Youtube video about it by user "Affected Collective".
The video links to
this page written by deuceofclubs about their interaction with the company.
Here's another
video discussing the product.
Here are a bunch of
images of it.
Another Smithsonian Institute page:
666 Double Action Cough Syrup - from 1985; "Pleasant Tasting"; contained Pyrilamine Maleate; Ephedrine Hydrochloride; Ammonium Chloride.
Part of why it intrigued me so much, as it did deuceofclubs and Affected Collective, is my surprise that a product named "666" could have survived and been popular, especially here in the bible belt.